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KMID : 0370219850290040188
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Yakhak Hoeji
1985 Volume.29 No. 4 p.188 ~ p.192
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Effects of Panax Ginseng on the Development of Morphine Induced Tolerance and Dependence(III) -Effects of Protopanaxadiol Fraction and Prtopanaxatriol Fraction in Mice-
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김학성/Kim HS
오세관/최강주/이해빈/Oh SK/Choi KJ/Lee HB
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Abstract
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Protopanaxadiol (PD) fraction and protopanaxatriol (PT) fraction were separated from the butanol fraction of panax ginseng roots. Each group of mice was injected with morphine hydrochloride (40mg/kg s.c.) three times at 8 hr intervals for a period of 6 days. PD fraction and PT fraction were injected (25, 100mg/kg i.p.) to mice 1 hr prior to the third morphine injection daily. Inhibition of morphine tolerance was evidenced by the increase in analgesic response to morphine hydrochloride (10mg/kg i.p.) as estimated by the tail flick method. Inhibition of morphine tolerance by PT fraction was effective but there was no remarkable difference in inhibition of tolerance development between control group and PD fraction group.
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